Publications

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Publications (Depuis 2000) 

  • Pincemail J, Christelbach S, Gillain S, Cheramy-Bien J-P, Dubrowski T , Dardenne N, Defraigne J-O, Petermans J. Delirium and oxidative stress. Poster P134 : OCC World Congress, Valencia (2015)
  • Rousseau A, Gillotin F, Chiap P, Bodoki E, Crommen J, Fillet M, Servais AC. Generic systems for the enantioseparation of basic drugs in NACE using single-isomer anionic CDs. J Pharm Biomed Anal., 5;54(1), 154-9 (2011)
  • Rousseau A, Gillotin F, Chiap P, Crommen J, Fillet M, Servais AC. Association of two single-isomer anionic CD in NACE for the chiral and achiral separation of fenbendazole, its sulphoxide and sulphone metabolites: application to their determination after in vitro metabolism. Electrophoresis., 31(9), 1482-7 (2010).
  • Francotte P, Goffin E, Fraikin P, Lestage P, Van Heugen JC, Gillotin F, Danober L, Thomas JY, Chiap P, Caignard DH, Pirotte B, de Tullio P. New fluorinated 1,2,4-benzothiadiazine 1,1-dioxides: discovery of an orally active cognitive enhancer acting through potentiation of the 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors. J Med Chem., 25;53(4), 1700-11 (2010).
  • F. Gillotin, P. de Tullio, J-Cl. Van Heugen, P. Francotte, M. Frédérich, P. Lebrun, P. Kremers, P. Chiap and B. Pirotte. Application of LC-SPE-NMR and LC-Q-TOF MS/MS to the structural determination of KATP channels openers metabolites belonging to the 3-alkylamino-4H-1,2,4-arylthiadiazine 1,1-dioxides. Drug Metab Dispos., 38(2), 232-40 (2010).
  • M.A. Bimazubute, E. Rozet, I. Dizier, J.-Cl. Van Heugen, E. Arancio, P. Gustin, J. Crommen, P. Chiap. Pre-study and in-study validation of an ultra-high pressure LC method coupled to tandem mass spectrometry for off-line determination of oxytetracycline in nasal secretions of healthy pigs, J. Chromatogr. B, 877, 2349-2357 (2009).
  • C. Cambier, M. Bimazubute, K. Baert, S. Vanbelle, P. Chiap, A. Albert, J.-P. Delporte and P. Gustin. Penetration of enrofloxacin into the nasal secretions in healthy pigs. Relationship between nasal secretions and plasma enrofloxacin concentrations, J. Vet. Pharmacol. Therapeut., 32, 147-148 (2009).
  • A. Rousseau, M. Pedrini, P. Chiap, R. Ivanyi, J. Crommen, M. Fillet and A.-C. Servais. Determination of flurbiprofen enantiomers in plasma using a single-isomer amino cyclodextrin derivative in nonaqueous capillary electrophoresis, Electrophoresis, 29, 3641-3648 (2008).
  • J. de Graeve, J.-C. Van Heugen, G. Zorza, J. Fahy and C. Puozzo. Metabolism pathway of vinorelbine (Navelbine®) in human: Characterisation of the metabolites by HPLC–MS/MS, J. Pharm. Biomed. Anal., 47, 47-58 (2008).
  • M.A. Bimazubute, E. Rozet, I. Dizier, P. Gustin, Ph. Hubert, J. Crommen and P. Chiap.Liquid chromatographic determination of enrofloxacin in nasal secretions and plasma of healthy pigs using restricted access material for on-line sample clean-up, J. Chromatogr. A, 1189, 456-466 (2008).
  • P. de Tullio, P. Chiap, P. Francotte, J.-Cl. Van Heugen, X. Florence, M. Frédérich, F. Gillotin, P. Kremers, P. Lebrun and B. Pirotte. In vitro metabolism study of several 3-alkylamino-4H-1,2,4-benzo-thiadiazine 1,1-dioxides as ATP-sensitive potassium channel openers : combined use of LC-Q-TOF MS/MS and LC-SPE-NMR, Fundamental & Clinical Pharmacology, 22 (2), 225 (2008).
  • E. Rozet, W. Dewé, R. Morello, P. Chiap, F. Lecomte, E. Ziemons, K.-S. Boos, B. Boulanger, J. Crommen and Ph. Hubert. Risk-based approach for the transfer of quantitative methods : bioanalytical applications, J. Chromatogr. A, 1189, 32-41 (2008).
  • G.B. Martin, P. Chiap, Ph. Paquet, G. Pierard, P. de Tullio, Y. Martin, E. Rozet, Ph. Hubert, J. Crommen and M. Fillet. Development of a mass spectrometry method for the determination of a melanoma biomarker, the 5-S-Cysteinyldopa, in human plasma using solid phase extraction for sample clean-up, J. Chromatogr. A, 1156, 141-148 (2007).
  • Ph. Hubert, J.-J. Nguyen-Huu, B. Boulanger, E. Chapuzet, P. Chiap, N. Cohen, P.-A. Compagnon, W. Dewé, M. Feinberg, M. Lallier, M. Laurentie, N. Mercier, G. Muzard, C. Nivet, L. Valat and E. Rozet. Harmonization of strategies for the validation of quantitative analytical procedures: a SFSTP proposal – Part II, J. Pharm. Biomed. Anal., 45, 70-81 (2007).
  • Y. François, A. Varenne, E. Juillerat, A.-C. Servais, P. Chiap and P. Gareil. Nonaqueous capillary electrophoretic behavior of 2-aryl propionic aicds in the presence of an achiral ionic liquid – A chemometric approach, J. Chromatogr. A, 1138, 268-275 (2007).
  •  W. Dewé, B. Govaerts, B. Boulanger, E. Rozet, P. Chiap and Ph. Hubert. Using total error as decision criterion in analytical method transfer, Chemometr. Intell. Lab. Syst., 85 (2), 262-268 (2007). 
  • G. Zorza, J.-C. Van Heugen, J. De Graeve and C. Puozzo. Development of a sensitive liquid chromatography method coupled with a tandem mass spectrometric detection for the clinical analysis of vinflunine and 4-O-deacetyl vinflunine in blood, urine and faeces, J. Chromatogr. B, 853, 294-302 (2007).
  • E. Rozet, R. Morello, F. Lecomte, G.B. Martin, P. Chiap, J. Crommen, K.-S. Boos and Ph. Hubert. Performances of a multidimensional on-line SPE-LC-ECD method for the determination of three major catecholamines in native human urine : validation, risk and uncertainty assessments, J. Chromatogr. B, 844, 251-260 (2006).
  • M. Piette, B. Evrard, F. Frankenne, P. Chiap, P. Bertholet, D. Castagne, J.-M. Foidart, L. Delattre and G. Piel. Pharmacokinetic study of a new synthetic MMP inhibitor (Ro 28-2653) after IV and oral administration of cyclodextrin solutions, Eur. J. Pharm. Sci., 28, 189-195 (2006).
  • R.D. Marini, A.-C. Servais, E. Rozet, P. Chiap, B. Boulanger, S. Rudaz, J. Crommen, Ph. Hubert and M. Fillet. Nonaqueous capillary electrophoresis method for the enantiomeric purity determination of S-timolol using heptakis(2,3-di-O-methyl-6-O-sulfo)-β-cyclodextrin : Validation using the accuracy profile strategy and estimation of uncertainty, J. Chromatogr. A, 1120, 102-111 (2006).
  •  A.-C. Servais, M. Fillet, R. Mol, G.W. Somsen, P. Chiap, G.J. de Jong and J. Crommen. On-line coupling of cyclodextrin mediated nonaqueous capillary electrophoresis to mass spectrometry for the determination of salbutamol enantiomers in urine, J. Pharm. Biomed. Anal., 40 (3), 752-757 (2006).
  • I. Fradi, A.-C. Servais, M. Pedrini, P. Chiap, R. Ivanyi, J. Crommen and M. Fillet. Enantiomeric separation of acidic compounds using single-isomer amino cyclodextrin derivatives in nonaqueous capillary electrophoresis, Electrophoresis, 27, 3434-3442 (2006).
  • R.D. Marini, P. Chiap, B. Boulanger, S. Rudaz, E. Rozet, J. Crommen and Ph. Hubert. LC method for the determination of R-timolol in S-timolol maleate : Validation of its ability to quantify and uncertainty assessment, Talanta, 68 (4), 1166-1175 (2006).
  • P. Chiap, M. Piette, B. Evrard, F. Frankenne, B. Christiaens, G. Piel, D. Cataldo, J.-M. Foidart, L. Delattre, J. Crommen and Ph. Hubert. Automated method for the determination of a new matrix metalloproteinase inhibitor in ovine plasma and serum by coupling of restricted access material for on-line sample clean-up to liquid chromatography, J. Chromatogr. B, 817, 109-117 (2005).
  • A. Ghuysen, J.-M. Dogné, P. Chiap, S. Rolin, B. Masereel, B. Lambermont, Ph. Kohl, V. Tchana-Sato, J. Hanson and V. D’Orio. Pharmacological profile and therapeutic potential of BM-573, a combined thromboxane receptor antagonist and synthase inhibitor, Cardiovasc. Drug Rev., 23, 1-14 (2005).
  • U. Gundert-Remy, S.G. Dahl, A. Boobis, P. Kremers, A. Kopp-Schneider, A. Oberemm, A. Renwick and O. Pelkonen. Molecular approaches to the identification of biomarkers of exposure and effect – Report of an expert meeting organized by COST Action B15, Toxicology Letters, 156, 227-240 (2005).
  • O. Rbeida, P. Chiap, D. Lubda, K.-S. Boos, J. Crommen and Ph. Hubert. Development and validation of a fully automated LC method for the determination of cloxacillin in human plasma using anion exchange restricted access material for sample clean-up, J. Pharm. Biomed. Anal., 36 (5), 961-968 (2005).
  • O. Rbeida, B. Christiaens, Ph. Hubert, D. Lubda, K.-S. Boos, J. Crommen and P. Chiap. Integrated on-line sample clean-up using cation exchange restricted access sorbent for the LC determination of atropine in human plasma coupled to UV detection, J. Pharm. Biomed. Anal., 36 (5), 947-954 (2005).
  • B. Christiaens, M. Fillet, P. Chiap, O. Rbeida, A. Ceccato, B. Streel, J. De Graeve, J. Crommen and Ph. Hubert. Fully automated method for the liquid chromatographic-tandem mass spectrometric determination of cyproterone acetate in human plasma using restricted access material for on-line sample clean-up, J. Chromatogr. A, 1056, 105-110 (2004).
  • B. Ouattara, L. Angenot, P. Guissou, M. Frédérich, J.-C. Van Heugen, J.-N. Wauters and M. Tits. LC/MS/NMR analysis of isomeric divanilloylquinic acids from the root bark of Fagara zanthoxyloides Lam., Phytochemistry, 65, 1145-1151 (2004).
  •  P. Kremers. In vitro tests for predicting drug-drug interactions: the need for validated procedures (a mini-review), Pharmacology and Toxicology, 91, 209-217 (2002).
  • A. Boobis, U. Gundert-Remy, P. Kremers, P. Macheras and O. Pelkonen. In silico prediction of ADME and pharmacokinetics – Report of an expert meeting organized by COST B15, Eur. J. Pharm. Sci., 17, 183-193 (2002).
  • M. Fillet, J.-C. Van Heugen, A.C. Servais, J. De Graeve and J. Crommen. Separation, identification and quantitation of ceramides in human cancer cells by liquid chromatography–electrospray ionization tandem mass spectrometry, J. Chromatogr. A, 949, 225-233 (2002).
  • P. Kremers. Can drug-drug interactions be predicted from in vitro studies? (a review article), The ScientificworldJOURNAL, 2, 751-766 (2002).
  • J.-C. Van Heugen, J. De Graeve, G. Zorza and C. Puozzo. New sensitive liquid chromatography method coupled with tandem mass spectrometric detection for the clinical analysis of vinorelbine and its metabolites in blood, plasma, urine and faeces, J. Chromatogr. A, 926, 11-20 (2001).
  • J. Géczy, J. Bruhwyler, J. Scuvée-Moreau, V. Seutin, H. Masset, J.-C. Van Heugen, A. Dresse, C. Lejeune, E. Decamp, L. Szente, J. Szejtli and J.-F. Liégeois. The inclusion of fluoxetine into γ-cyclodextrin increases its bioavailability: behavioural, electrophysiological and pharmacokinetic studies, Psychopharmacology, 151, 328-334 (2000).
  • J. Broekhuysen, A. Stockis, R.L. Lins, J. De Graeve and J.F. Rossignol. Nitazoxanide: pharmacokinetics and metabolism in man, Int. J. Clin. Pharmacol. Ther., 38, 387-394 (2000).