Bioanalysis

BIONALYTICAL STUDIES

  • Development and validation of sensitive and selective methods
  • Application of bioanalytical methods:
    • Determination of drugs, metabolites and drug residues in different biological matrices
    • Pharmacokinetic studies in human and animals
    • Trace analysis of drug residues in tissues and biological fluids (veterinary studies)

AVAILABLE INSTRUMENTATION

Chromatography ­:
  • HPLC coupled with UV, DAD or fluorescence detection
  • UPLC-MS/MS
  • LC-MS/MS
  • High-throughput metabolism research: UPLC Q-TOF
  • GC-MS, GC-MS/MS
3H- and 14C-labelled drugs :
  • HPLC with radioactivity detection
  • beta counter, oxidiser
Sample storage capacity :
  • Large storage capacities at +4 ° C, -20° C and -80° C
Bioanalytical methods (partial non-confidential list) :

Acetylcysteine

Acetylsalicylate

Albendazole

Alprenolol

Ampicillin

Betaxolol

Bromazepam

Bupivacaine

Camazepam

Captopril

Ceftiofur

Celiprolol

Chlorpromazine

Ciprofibrate

Clembuterol

Clindamycine

Clotrimazole

Dexamethasone

Dextromethorphan

Diazepam

Diclofenac

Diltiazem

Econazole

Estradiol/Estrone

Etazolate

Fenofibrate

Fluoxetine

Gallopamil

Indometacine

Ketotifen

Levamizole

Levonorgestrel

Lincomycinel

Mepivacaine

Methylphenobarbital

Metipranolol

Metoclopramide

Miconazole

Molsidomine

Nicorandil

Nicotine

Nifedipine

Nitrates

Nordazepam

Norverapamil

Oleylamine

Oxprenolol

Oxybutynin

Phenobarbital

Phenylbutazone

Pindolol

Piracetam

Pirlindol

Prilocaine

Progesterone

Propoxyphene

Propranolol

Sotalol

Sulfamethazine

Sulfamethoxazole

Tienoxolol

Tramadol

Tricyclics

Trimetazidine

Trimethoprime

Verapamil

Vinblastine

Vinflunine

Vinorelbine

     

 

OTHER AVAILABLE INSTRUMENTATION

Collaboration with the Interfacultary Centre of Drug Research (CIRM) of the University of Liège :

Department of Medicinal Chemistry (Prof. B. Pirotte), Institute of Pharmacy

  • LC-RMN

Department of Analytical Pharmaceutical Chemistry (Prof. J. Crommen), Institute of Pharmacy

  • LC coupled with UV, DAD, electrochemical and fluorescence detection
  • LC-MS/MS
  • GC-FID
  • Capillary electrophoresis (CE) coupled with UV detection
  • Automated sample preparation systems (ASPEC, column switching modules, …)

Laboratory of Analytical Chemistry (Prof. Ph. Hubert), Institute of Pharmacy

  • Polarography (determination of selenium in biological fluids)

OTHER SERVICES

Collaboration with ARLENDA, spin-off company from the University of Liège, whose mission is to integrate a suite of solutions for the analytical laboratory, from the optimisation to the routine.

  • Validation, Robustness and Transfer of (bio)analytical methods
  • Experimental design (optimization strategies)
  • Uncertainty assessment