BIONALYTICAL STUDIES

• Development and validation of sensitive and selective methods
• Application of bioanalytical methods:
  • Determination of drugs, metabolites and drug residues in different biological matrices
  • Pharmacokinetic studies in human and animals
  • Trace analysis of drug residues in tissues and biological fluids (veterinary studies)

AVAILABLE INSTRUMENTATION

Chromatography ­:

• HPLC coupled with UV, DAD or fluorescence detection
• UPLC-MS/MS
• LC-MS/MS
• High-throughput metabolism research: LC Q-TOF (see next page)
• GC-MS, GC-MS/MS

3H- and 14C-labelled drugs :

• HPLC with radioactivity detection
• beta counter, oxidiser

Sample storage capacity :

• Large storage capacities at +4 ° C, -20° C and -80° C

Bioanalytical methods (partial non-confidential list) :

OTHER AVAILABLE INSTRUMENTATION

Collaboration with the Interfacultary Centre of Drug Research (CIRM) of the University of Liège :

Department of Medicinal Chemistry (Prof. B. Pirotte), Institute of Pharmacy

• LC-RMN

Department of Analytical Pharmaceutical Chemistry (Prof. J. Crommen), Institute of Pharmacy

• LC coupled with UV, DAD, electrochemical and fluorescence detection
• LC-MS/MS
• GC-FID
• Capillary electrophoresis (CE) coupled with UV detection
• Automated sample preparation systems (ASPEC, column switching modules, …)

Laboratory of Analytical Chemistry (Prof. Ph. Hubert), Institute of Pharmacy

• Polarography (determination of selenium in biological fluids)

OTHER SERVICES

Collaboration with ARLENDA, spin-off company from the University of Liège, whose mission is to integrate a suite of solutions for the analytical laboratory, from the optimisation to the routine.

• Validation, Robustness and Transfer of (bio)analytical methods
• Experimental design (optimization strategies)
• Uncertainty assessment